Only to continue what Xavier said, in case the implications of not generating/using thumbnails aren't clear:
The main images will be used = loaded everywhere, e.g. also in product listings. Depending on their file sizes, your pageload times may go up astronomically.
Example: If your main image is lots of pixels and 2MB in size for proper display in the popup on the product page, without thumbnails it will load these images also in product listings, where you might want only say 180x120px or so. Imagine 20 products in a listing... it would take ages to load all those images, even though they appear very small. Thumbnails as per your values in the configuration are only few kB.
Similar, even if maybe not as dramatic, for images on the product page ("before" popup), unless you wanted them to take the whole page width or so.